Solving Dominance Next-generation sequencing (NGS) revolutionized understanding of our morbid anatomy at a single-nucleotide resolution. As with traditional genetics, solving autosomal-recessive conditions via NGS has been highly successful. Solving genetic dominance, i.e., identifying single-allele autosomal or X-chromosome genes and variants with clinical relevance, has lagged behind. Now, that set of hurdles might also be crumbling thanks to a DOMINO effect that utilizes a machine-learning approach designed by DOMINO is a simple-to-use, web-based predictive tool that is complementary but distinct from available haploinsufficiency-based methods. It utilizes well-known resources such as ExAC together with other measurements, e.g. MRNA stability in mouse embryonic stem cells.

DOMINO is shaping up to be a useful adjudicator for a modern dominant-gene and variant hunter. Mvno Business Plan With Financial Modeling Spreadsheet.

Now in its thirteenth year of publication, Human Molecular Genetics has become one of the leading journals in this exciting frontier of scientific research. The journal concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics.

AJHG publishes peer-reviewed research and review articles relating to heredity in humans and to the application of genetic principles in medicine and public policy. Warning: Invalid argument supplied for foreach() in /srv/users/serverpilot/apps/jujaitaly/public/index. Antonio Jose Sonata Pdf Creator. php on line 447.

These include: the molecular basis of human genetic disease; developmental genetics; cancer genetics; neurogenetics; chromosome and genome structure and function; gene therapy; mouse and other models of human diseases; functional genomics; and computational genomics. In addition, the journal also publishes research on other model systems for the analysis of genes, especially when there is an obvious relevance to human genetics. Already subscribed to this product through your institution?